Although the mouse has served well as the workhorse model in experimental research, another animal—the zebrafish—is becoming a model of choice for a large number of biomedical, toxicological, and developmental research objectives focused on improving our understanding of human disease.
Zebrafish (Danio rerio), in fact, share nearly 12,800 genes in common with humans, 84 percent of which can be linked to genes that cause disease in humans, such as heart disease, anemia, leukemia, melanoma, muscular dystrophy, kidney disorders, Alzheimer’s, and eye diseases. Thus, studying how zebrafish genes react and respond to new cancer drugs or other disease treatment strategies, for example, serves as an indicator of similar reaction endpoints in humans, and can be used to determine critical parameters of health and disease such as the safety and efficacy of drugs prior to human (or other animal) therapies.
The CEB maintains a zebrafish colony and provides zebrafish to UT researchers under appropriate animal use IACUC protocols. We also have microinjection equipment for the insertion of nucleic acid into zebrafish embryos.
If you are interested in using zebrafish in your research or require more information on zebrafish, please contact us.